Serotonin transporter polymorphism and bleeding time during SSRI therapy
نویسندگان
چکیده
منابع مشابه
association between serotonin transporter gene polymorphism and recurrent aphthous stomatitis
background: anxiety-related traits have been attributed to sequence variability in the genes coding for serotonin transmission in the brain. two alleles, termed long (l) and short (s) differing by 44 base pairs, are found in a polymorphism identified in the promoter region of serotonin transporter gene. the presence of the short allele and ss and ls genotypes is found to be associated with the ...
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Serotonin specific reuptake inhibitors (SSRI) may induce antinociception however, the mechanism of this effect is not clear. SSRls increase 5-HT levels in neuronal synapses and facilitate serotonergic activity. In this study, therefore, the activity of para-chlorophenylalanine (pCPA), which reduces 5-HT release, and 5- hydroxy tryptophan (5-HTP), a precursor of 5-HT, were examined on the a...
متن کاملSerotonin transporter promoter polymorphism influences topography of inhibitory motor control.
The prefrontal cortex participates in motor control and is modulated by serotonergic activity. The serotonin transporter (5-HTT) is a major regulator of serotonergic neurotransmission and may thus influence motor control. The short allele (s) of the 5-HTT linked polymorphic region (5-HTTLPR) is associated with less 5-HTT expression and function than the long variant (l). The neurophysiological ...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2008
ISSN: 0306-5251,1365-2125
DOI: 10.1111/j.1365-2125.2008.03098.x